Thymidylate synthase gene of herpesvirus ateles
نویسندگان
چکیده
منابع مشابه
trans activation of the thymidylate synthase promoter of herpesvirus saimiri.
Herpesvirus saimiri has been shown to possess a thymidylate synthase (TS) gene that is unusual in its transcriptional regulation. Although TS is believed to be required for viral DNA synthesis, the TS-specific 2.5-kb mRNA was found most abundantly during the late phases of asynchronous virus replication in permissive cultures. To study the kinetics of gene activation, the TS promoter and regula...
متن کاملPrimary structure of the Herpesvirus ateles genome.
Herpesvirus ateles is an agent indigenous to spider monkeys (Ateles spp.) and causes fulminant lymphomas in various New World primates. Structural and genetic relatedness led to the classification of this virus as a member of the genus Rhadinovirus. It is most closely related to Herpesvirus saimiri. The 108,409-bp light DNA segment of the herpesvirus ateles strain 73 genome has two genes for U-...
متن کاملmolecular characterization of dihydrofolate reductase-thymidylate synthase gene concerning antifulate resistance of plasmodium vivax
background: the recently reported resistance to antimalarials contributes to making the control of malaria more difficult. there is a need to evaluate the current antimalaria regimens to prevent this emerging problem. the aim of this study was to determine dihydrofolate reductase-thymidylate synthase gene mutation ( pvdhfr ) regarding antifulate resistance in plasmodium vivax . methods : from...
متن کاملIsolation and expression of the Pneumocystis carinii thymidylate synthase gene.
The thymidylate synthase (TS) gene from Pneumocystis carinii has been isolated from complementary and genomic DNA libraries and expressed in Escherichia coli. The coding sequence of TS is 891 nucleotides, encoding a 297-amino acid protein of Mr 34,269. The deduced amino acid sequence is similar to TS from other organisms and is most closely related to the enzyme from Saccharomyces cerevisiae wi...
متن کاملBidirectional promoter of the mouse thymidylate synthase gene.
The promoter of the mouse thymidylate synthase (TS) gene lacks both a TATAA box and an initiator element and directs transcriptional initiation at multiple sites over a 90 nucleotide initiation window. Earlier studies defined an essential region near the 5' end of the initiation window that is required for promoter activity. The essential region contains possible binding sites for Sp1 and Ets t...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1988
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.62.9.3530-3535.1988